Sickle Cell Anemia

HBB: The Gene Associated with Sickle Cell Anemia Approximate constituent fixing is based on Chromosome 11 map from NCBI Entrez mapping Viewer. authoritative Gene Symbol: HBB Name of Gene fruit: hemo hematohiston, of import Alternate Name of Gene Product: master(prenominal) globin venue: 11p15.5 - The HBB divisor is base in theatrical role 15.5 on the con (p) arm of human chromosome 11. Gene social system: The normal allelomorphic variant for this gene is 1600 base pairs (bp) colossal and contains three exons. template RNA: The intron-free messenger RNA transcript for the HBB gene is 626 base pairs long. See the NCBI eon mark NM_000518 to access the template RNA sequence data. Coding era (CDS): 444 base pairs within the mRNA code for the amino group group caustic sequence of the genes protein product. Protein Size: The HBB protein is 146 amino acids long and has a molecular(a) weight of 15,867 Da. See the annotated HBB protein seq uence record in Swiss-Prot. Protein belong: Hemoglobin sh cherry- wilds, which reside in red blood cellph unmatchables, atomic number 18 responsible for carrying oxygen from the lungs to various parts of the body for mapping in respiration. The HBB gene codes for one of the ii types of polypeptide chains found in grownup hemoglobin. Normal adult hemoglobin is a tetrameric protein consisting of two important chains and two of import chains. HBB codes for the beta chain, which is often referred to as beta globin. Mutant beta globin is responsible for the sickling of red blood cells seen in sickle cell anemia. Protein Structure The social organization of normal deoxy hemoglobin is shown in ascertain 1. The four grayness clusters ar noncovalently bonded hematin groups. Each heme serves as a contact site for binding one molecule of oxygen. The two bullion spheres near the top of the molecule are inorganic phosphate groups. The green and blue chains are alpha ch ains, and the gold and aqua chains are beta ! chains. The red corner highlights the general region of two beta chains where the sixth glutamic acid residue is located. A inheritable variant associated with this amino acid...If you want to get a all-inclusive essay, order it on our website: BestEssayCheap.com

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